Kisspeptin-10 (HPTA Restart) | 5mg – 10mg | >99% Purity

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69.99
89.99
Chemical Specifications
Product Name Kisspeptin-10 (KP-10 / Metastin 45-54)
CAS Number 374675-21-5
Peptide Sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Molecular Formula C63H78N18O13
Molecular Weight 1302.45 g/mol
Purity (HPLC) ≥ 99.0%
Appearance White Lyophilized Powder
Storage Store at -20°C (Protect from light and moisture)
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          Description
          🔑

          What is Kisspeptin-10 (KP-10)?

          Kisspeptin-10, supplied in commanding 5mg to 10mg research vials, is universally recognized in endocrinology as “The Ultimate HPTA Switch”. It is the most biologically active decapeptide fragment of the Kiss1 gene product. Unlike exogenous testosterone (which shuts down your natural production) or hCG (which only mimics LH at the testicular level), Kisspeptin-10 operates at the absolute apex of the endocrine hierarchy. It violently activates the hypothalamus, acting as the primary upstream trigger for Gonadotropin-Releasing Hormone (GnRH). For advanced researchers dealing with severe Hypothalamic-Pituitary-Testicular Axis (HPTA) suppression, KP-10 is the nuclear option for restarting the body’s natural testosterone engine and reversing testicular atrophy.

          Key Features & Research Protocols

          🔄

          Complete HPTA Restart

          Acts as the master ignition key for the endocrine system. It breaks through deep hormonal suppression by violently waking up the hypothalamus, forcing the central nervous system to resume natural hormone cascades.

          🌊

          LH & FSH Tsunami

          By unleashing GnRH, it commands the anterior pituitary to secrete a massive, immediate surge of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH)—the two critical signals for male hormonal health.

          🧬

          Endogenous Testosterone Trigger

          Instead of replacing testosterone, it commands your Leydig cells to manufacture it naturally. This avoids the negative feedback loop associated with TRT, preventing testicular shrinkage and hormonal dependency.

          🛡️

          The Holy Grail of PCT

          Considered the most advanced compound for Post-Cycle Therapy (PCT). It rescues the HPTA from the severe shutdown caused by exogenous anabolic suppression, radically accelerating the recovery timeline.

          🌱

          Fertility Restoration

          Because it triggers massive FSH release alongside LH, Kisspeptin-10 is a top-tier research compound for stimulating Sertoli cells, enhancing spermatogenesis, and reversing chemically induced infertility.

          💎

          Massive Lab-Grade Dosing

          Supplied in massive 5mg-10mg bulk vials. This ≥99.0% pure decapeptide ensures researchers have the required volume to run extended, high-dose HPTA-restart protocols without interruption.

          How It Works: “Hotwiring” the Endocrine Engine

          To understand the nuclear-level power of Kisspeptin-10, you must understand the “Chain of Command” in human endocrinology. The Hypothalamic-Pituitary-Testicular Axis (HPTA) operates from the top down. The Hypothalamus (the general) sends GnRH to the Pituitary (the captain), which sends LH and FSH to the Testes (the soldiers) to produce testosterone and sperm. When a subject uses exogenous hormones (like steroids or TRT), the Hypothalamus senses too much testosterone and completely shuts down GnRH production. The entire axis crashes.

          Compounds like hCG only bypass the brain and directly yell at the testes. Selective Estrogen Receptor Modulators (SERMs) trick the brain by blocking estrogen. Kisspeptin-10 is different. It is the molecular “master key” that sits even higher than GnRH.

          When administered, Kisspeptin-10 binds directly to the GPR54 receptors located on the GnRH neurons in the hypothalamus. It effectively “hotwires” the system, violently forcing these neurons to dump a massive pulse of Gonadotropin-Releasing Hormone (GnRH), regardless of the current suppressive feedback loop. This GnRH tsunami hits the pituitary gland, which then fires massive, natural pulses of LH and FSH. The LH hits the Leydig cells, triggering an explosive resumption of endogenous testosterone production, while the FSH hits the Sertoli cells to kickstart spermatogenesis. It is a true, top-to-bottom physiological reboot, making it the absolute pinnacle weapon for advanced Post-Cycle Therapy (PCT) and anti-aging testosterone optimization.

          🧪 What’s In The Vial

          • Active Compound: Kisspeptin-10 (KP-10)
          • Structure: Biologically Active Decapeptide
          • State: Sterile, Lyophilized Powder
          • Net Contents: Bulk 5mg or 10mg
          • Purity: ≥99.0% (HPLC Verified)

          👩‍🔬 Who Uses It

          • Advanced PCT (Post-Cycle Therapy) Researchers
          • Endocrinology & HPTA Axis Labs
          • Fertility & Spermatogenesis Investigators
          • Anti-Aging / Natural TRT Analysts
          • Hypogonadism Research Specialists

          🔗 Best Paired With

          • Sterile Bacteriostatic Water (BAC)
          • Enclomiphene / Clomid (For dual-pathway HPTA rescue)
          • hCG / HMG (In alternating advanced PCT protocols)
          • Zinc & Magnesium (For foundational Leydig cell support)